Monasterolo di Savigliano, January 22, 2014
Dr. Sergio Chiamparino – President of the Foundation “Compagnia di San Paolo”
Dr. Carlo Bongiovanni – Assistant to the President
Dr. Luca Remmert – Vice President
Dr. Piero Gastaldo – Segretary General
Dr. Stefano Scaravelli – Responsable area Health Care and Scientific Research
Dr. Amalia Bosia – Board Member of the Foundation “Compagnia di San Paolo”
Dr. Giorgio Palestro – Board Member of the Foundation “Compagnia di San Paolo”
C.so Vittorio Emanuele II, 75 – 10128 Torino
Thirteen years after publication of Crosetto’s book  and scientific articles , in which he describes the feasibility and benefits of the innovative 3D-CBS, (3 Dimensional Complete Body Screening), hundreds of times more efficient than the current PET (Positron Emission Tomography), representatives of three of the most important U.S. universities, which had always denied the possibility to significantly improve the efficiency of the over 5,000 PET currently used in hospitals, instead now recognize  that it is feasible and that the increased efficiency can reduce the radiation to the patient to below 0.1 mSv. They also agree that it can provide other significant benefits to the patient.
Siemens also denied such a possibility; however, after the President of Siemens Nuclear Medicine and the Director of PET spent an entire day with Crosetto at his premises in DeSoto, Texas, on November 6, 2002, and after a series of subsequent conference calls between Crosetto and the leaders of the company, they changed their minds about the limits of feasibility that they had considered insurmountable.
Flavio Marchetto, a physicist from Turin, has just put in writing that he considers Crosetto’s invention feasible. He believes it is time for clinicians to decide to make a statement on the extent of the benefits to patients from the increased efficiency of the 3D-CBS innovative technology. The 3D-CBS is a new PET/CT with the potential to replace many tests such as the mammogram, colonoscopy, etc., with an effective single screening test to detect cancer and other diseases in most organs of the body at an early, curable stage. It provides more accurate information on minimum abnormal biological processes, quantified with a ratio between the measured value and the standard value. The increased sensitivity and specificity of the 3D-CBS device makes it possible to have a more accurate staging of the disease, the identification of micro-metastasis, the precise measuring of the cancer activity, inflammation, infections, diabetes, Alzheimer’s, heart and vascular diseases, etc. Its increased sensitivity opens the door to the discovery and development of new biomarkers that cannot be detected with the current inefficient PET, thus making their discovery difficult.
Many public scientific reviews that have compared Crosetto’s 3D-CBS innovative project with major projects in the field have proven its superiority, even winning the Leonardo da Vinci competition for the most efficient solution in particle detection for early cancer diagnosis (this contest was also sponsored by Dr. Chiamparino in his then position as President of ANCI).
In view of the above delays in the recognition of the validity of Crosetto’s inventions as an effective tool for the discovery of new particles and early cancer detection aimed at the reduction of premature cancer death, and in order to allow a more rational use of public resources in these areas of research, it is urgent and imperative to address this issue.
Without further hesitation, clinicians should decide to recognize the potential diagnostic and therapeutic benefits made possible when a detailed, accurate map of the abnormal biological processes at the cellular level is provided. This opportunity must not be ignored or dismissed within the scientific community, and particularly in medical physics. Crosetto and his team are readily available to answer any questions and to gain your support, eliminating whenever possible your doubts through calculations, logical reasoning, and experiments, so that the 3D-CBS can be funded as soon as possible.
It is urgent to tackle the global issue of funding research projects questioning the same criteria that guided the definition of the regulations in the various public institutions and/or funding agencies. The process and goals set by these regulations are often the main obstacles to the development of projects/applications that are truly innovative for the benefit of knowledge and humanity. We can no longer allow inventions such as those made by Crosetto to be ignored because they are tangled up in “networks” of regulations that more often favor the business of the companies rather than the advancement of knowledge and utilization of life changing inventions.
This distortion over the past 50 years has had serious consequences that are in the eyes of all: The treatment cost of cancer has increased a hundred-fold, reaching a total annual economic cancer cost of more than 1,100 billion dollars, with a paltry mortality reduction rate of only 5%, mostly as a result of abstention from smoking or other changes in lifestyle, and not due to the merits of research.
The reason for calling this meeting, and we thank you for granting it, cannot be reduced to a simple request for a contribution to research and experiment. Instead, it is aimed to efficiently (cost-effectively) address and resolve in the shortest amount of time, one of the greatest calamities that afflicts our planet (ref. Crosetto’s book ): cancer. We believe that this ambitious and essential goal unites the “Compagnia di San Paolo” and the association “Crosetto Foundation for the reduction of premature cancer deaths,” as evidenced in some areas of your own papers which state: ” The Compagnia shall pursue goals of social good, to foster civil, cultural and economic development, by operating in particular in the following sectors: scientific, economic and juridical research; education; art; conservation and enhancement of cultural heritage and activities and of heritage sites; health; assistance to the socially deprived categories. Such sectors are defined collectively in these articles of association as the Compagnia’s priority sectors of activity.” Let us then face together and promote a dialogue on these issues in order to objectively analyze and understand what has been achieved as a result of the investments made, and to ensure that opportunities offered by currently available knowledge are properly supported and encouraged.
The Association of the Crosetto Foundation therefore submits two proposals to the Compagnia di San Paolo which has the common goal of achieving maximum effectiveness in solving the most macroscopic and urgent problems faced by humanity. In the event the Company would identify more efficient methods or be deemed to modify the proposal, the Crosetto Foundation will be pleased to address these proposals in a constructive dialogue for the benefit of humanity.
The proposals are as follows:
- In accordance with the description on page 17 of the document “DPP_2013 -2016″ of the Compagnia di San Paolo on the “Dissemination of scientific culture”, we proposed for the Compagnia di San Paolo to participate and contribute to the activities carried out by the Crosetto Foundation for the last few years with the goal of building a stable connection and an effective communication at the scientific level between the leaders of the various areas of scientific research and citizens who largely finance and receive the
benefits of scientific research. More specifically, the Crosetto Foundation will include the Compagnia di San Paolo among the recipients of these communications attached hereto as Exhibit A, which shows the dialogue between those responsible for managing the funds and evaluating research projects, and those who propose solutions. It is expected by cancer patients, who are the recipient of the benefits that reviewers and proposers jointly motivate how their proposals and decisions to support or reject funding are consistent with the achievement of a significant reduction in premature cancer deaths and costs.
2. In light of the above invention made by Crosetto and its high potential to contribute to the reduction of premature cancer deaths and cost, it is proposed to the Compagnia di San Paolo to support (with a contribution to get started, avoiding adding delay of the benefits) the construction of three 3D-CBS prototypes targeted to early cancer detection with an affordable examination cost. This important objective will be achieved without further delay in the transfer of innovations to the bedside, with an immediate support to the Association of the Crosetto Foundation to create the infrastructure that makes it possible to start a joint work plan directed at defining costs, financing instruments and operating modes. In preparation for these activities, we point out the availability of Flavio Marchetto in making his expertise in medical physics available for comparison with your experts at a later meeting on Friday, January 24, 2014, with the understanding there may be additional meetings to openly support the need for constant scientific comparison.
In order to facilitate the understanding of the substantial documentation concerning this project and Crosetto’s inventions, below this letter you will find references to two recent articles in one page and 32 pages summarizing twenty years of obstacles and recognitions of Crosetto’s inventions. Below this you will find documents related to Crosetto’s inventions on page 1, 3,, 5, 14, 20 , 29, 32, 45, 55 , 70, and 260. The reader may stop reading at the level of detail he chooses and at any time may ask questions directly to the inventor, who will answer as satisfactorily as possible, even publicly, in order to render a service to others.
Crosetto has pledged to make a donation on behalf of cancer patients with80 % of the proceeds from the licensing of his patents.
Currently the Crosetto Foundation is funded as follows:
- Permanent ongoing contributions from the membership fees;
- Contributions at events, support for the publication of books;
- From crowd-funding fundraising, donations in memory of victims of cancer;
- Contributions by payment of five per thousand (in compliance with the Italian law that gives taxpayers the option to choose the beneficiary of their contribution).
On behalf of the members of the Crosetto Foundation to defeat premature mortality from cancer,
DIALOGUE between Crosetto and decision -makers in the field of particle detection and medical imaging, and people who care to contribute to make a better world. http://links.u2ec.net/doc2/806.pdf
References to recent documents of one page and of 32 pages and an 11-minute video that describes the 3D-CBS technology.
 One page article submitted at the Conference ” IEEE : the Grand Challenges of Science for Life” – 2-3 December 2013 , Singapore, and at the Workshop “The use of PET in the diagnosis of diseases of the nervous system. News and Perspectives” – January 13, 2014, National Neurological Institute C. Mondino, Pavia. http://links.u2ec.net/doc2/804.pdf
 11-minute video describing the 3D-CBS technology: www.youtube.com/watch?v=HwMnHRuWo4o
 32-page article summarizing Crosetto’s innovations over the last 20 years, which prove to be “beyond the imagination of future science”. The article was presented at the Conference IEEE- NSS- MIC- RTSD held in Seoul, Korea, from October 27 to November 2, 2013. Title: “Breaking the Speed Barrier in Real-Time Applications to Make Advances in Particle Detection, Medical and Astrophysics.” IEEE- NSS- MIC- RTSD. Conf Rec R05 -52 , 2013. http://links.u2ec.net/doc2/800.pdf
References of documents from one page up to 260 pages.
 1 page document describing the innovative architecture of the 3D-Flow Crosetto for the First Level Trigger: http://www.crosettofoundation.com/uploads/291.pdf
 1 page document describing Crosetto’s additional inventions for applications in medical diagnostics. Page summary of the main innovations of the 3D-CBS technology. The key elements are grouped into five main areas. The innovative electronics allow significant efficiency improvement in a simplified assembly of the detector which in turn allows changes in the ability to execute complex algorithms in real time. Additional innovations, such as those that make possible the use of less expensive crystals which allows to increase the length of the detector ( FOV) of the entire device at a reasonable cost, can be obtained as a result of the combination of the preceding innovations. See www.crosettofoundation.org/uploads/254.pdf. Also compare slides 40 , 41, 44 , 47, 48 and 50 of the seminar at: www.UnitedToEndCancer.org/doc/60.pdf
 3 page document for laymen in English at http://www.crosettofoundation.com/uploads/177.pdf or in Italian at http://www.crosettofoundation.com/uploads/177.it.pdf
 5 page article published in 2003 in English: “Complete Body Screening, 3D-CBS: Features and Implementation”, presented at IEEE-NSS-MIC-2003. Conference Record. M7-129 . www.crosettofoundation.com/uploads/107.pdf or in Italian at: http://www.crosettofoundation.com/uploads/107.it.pdf
 6 to 14 page article published in 1992, that describe the innovative 3D-Flow architecture. Within 35 days, Crosetto presented his basic invention at three international conferences, in Europe, Annecy, and the United States, Corpus Christi (Texas ) and Orlando ( Florida ), respectively, and published in prestigious scientific journals: Nuclear Instruments and Methods in Physics Research, and IEEE -NSS -MIC . See www.crosettofoundation.org/uploads/420.pdf.
[9 ] 8 and 20 page articles presented to the Conference by Crosetto at IEEE Nuclear Science Symposium and Medical Imaging in Lyon, France, in 2000, the IEEE -2000-563, and IEEE- www.crosettofoundation.org/uploads/69.pdf 2000-567 http://www.crosettofoundation.com/uploads/99.pdf.
 20 page document. Recognition of innovations made by Crosetto by an international auditing at Fermilab, simulation and demonstration of feasibility in hardware http://links.u2ec.net/doc2/300.pdf
 22 page questionnaire compiled by the inspectors of the ABO Project, who reviewed the entire project for four days in Dallas, TX, during 17 hours of meetings (all videotaped). They approved and witnessed the benefits of the system. See www.crosettofoundation.org/uploads/162.pdf
 29 page article. Title: “Logical Reasoning and Reasonable Answers Consistent with Declared Objectives for the Benefit of Mankind.” Presented by Crosetto at the International Seminars on Planetary emergencies 40th Session, Erice, 19-24 August 2008. Editor: World Scientific 2009, p. 531. www.crosettofoundation.com/uploads/211.pdf
 45 page article published in NIM in 1999. Title: “Base Implementation of the LHCb Trigger Level-0 with the 3D-Flow system,” in Nuclear Instruments and Methods in Physics Research, Sec A, vol. 436 (1999), p.341-385.Part 1: http://www.crosettofoundation.com/uploads/147.it.pdf Part 2: http://www.crosettofoundation.com/uploads/148.pdf
 55 page article presented at the University of Geneva in 2001: http://www.crosettofoundation.com/uploads/100.pdf
[15 ] 70 page book for laymen entitled: “The Future is in Our Hands . EVERY YEAR : 10 million preventable deaths, trillions of Euros LOST ” http://links.u2ec.net/doc2/100.pdf.
 260 page technical and Scientific book published by Crosetto presented at the IEEE Nuclear Science and Medical Imaging Symposium, Lyon , France, in 2000 , entitled : “Improvement of the Efficiency of the PET 400 Times”, reducing the radiation dose and low-cost screening for cancer. see www.crosettofoundation.org/uploads/431.pdf