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Information, Awareness, Prevention / United to End Cancer

Fourteen years ago the technological innovations of the Crosetto 3D-CBS technology which enabled effective early cancer detection by improving the efficiency of PET by 400 folds, were presented in two articles and a book distributed free to the leaders in the field at the 2000 IEEE-NSS-MIC conference in Lyon, France.

From: Dario Crosetto (mailto:crosetto@att.net)
Sent: Friday, May 09, 2014 2:47 PM
To: ‘Georges El Fakhri, PhD, DABR’; ‘katia.parodi@lmu.de’
Cc: unitedtoendcancer@att.net;

Subject: Submission of a half-day MIC workshop at the 2014 IEEE-NSS-MIC conference in Seattle (WA), Nov. 8 to Nov. 15, 2014

Dear Georges and Katia,

According to your instructions on how to prepare a proposal for a workshop, we drafted the following proposal that I am sending you a few days before the deadline of Sunday May 11, 2014 because Katia mentioned on the phone that you would have the meeting on Monday May 12 to evaluate these proposals and if we need to change format/length, etc. there would still be the time.

We have paid attention to Katia’s advice that the workshop topics  should not be the same as in the regular conference, and that they should require discussion of new ideas for advancement of future science.

In the proposed workshop the topic: a) links each project to the ultimate objective (e.g. of reduction of cancer deaths and cost) which is not listed in any regular topic of the conference, b) asks researchers to make an estimate of the percentage in reduction of cancer deaths and cost they expect to attain with their research, either stand alone or when combined with existing components or current research, is not in the regular topic, c) is not limited to a single modality, but rather open to all modalities PET/CT, PET/MRI, PET/Ultrasound, TOF-PET and any other modality a proposer can demonstrate would achieve a significant reduction of cancer death and cost, d) seeks to identify a standard measurement of the efficacy of a proposed solution which is not in the standard topics. The fact that there are many protocols for trials of new drugs and new imaging devices but during the past 50 years premature cancer deaths did not drop significantly demonstrates the need for the novel approach proposed in this workshop.

Our workshop will allow the discussion to span across all modalities, techniques, linking a technique with the ultimate goal of reducing cancer deaths, and is not available in the regular topics.  Also, within a modality, there is no link in the regular topic with the ultimate goal. For example, now people are trying to improve TOF-PET from 600 picosecond (corresponding to 18 mm resolution) to 200 picosecond (corresponding to 6 mm resolution). Is there an estimate of saving more lives and reducing cost using a PET with 200 picosecond resolution?  If so, how is the estimate calculated? The expectations we have in reducing cancer deaths with the trend of technological improvements should be clear as we plan now for the future.

We believe the benefits of the dialogue from the proposed workshop would be substantial for the scientific community as well as for humanity.

Because an open public DIALOGUE is key to bring maximum benefits to humanity from innovations that are providing advancement in science and in significantly reducing cancer deaths through an effective early detection, Crosetto Foundation for the Reduction of Cancer Deaths will cover the cost of the broadcasting and of the interactive discussion via internet EVO system of the event.

We hope to receive your approval,

Kind Regards,

Dario Crosetto, Umberto Bellotti, Joseph Dent and Ruben Sonnino

 

PROPOSED WORKSHOP

How does your project/idea/invention in Medical Imaging compares to other projects in advancing science and in particular in reducing cancer deaths and cost?

Sunday, November 9th, 2014, 13:30- 18:00

Location: TBD

Chairs: Umberto Bellotti, BELLUM Labs.

Dario Crosetto, Crosetto Foundation for the Reduction of Cancer Deaths

Joseph Dent, McGill University, Montreal, Canada

Ruben Sonnino, Retired executive of ST-Microelectronics. Active member of ST-Foundation, responsible for North, Central and South America

Fourteen years ago the technological innovations of the Crosetto 3D-CBS technology which enabled effective early cancer detection by improving the efficiency of PET by 400 folds, were presented in two articles and a book distributed free to the leaders in the field at the 2000 IEEE-NSS-MIC conference in Lyon, France.

Today the challenge Crosetto set for himself in the year 2000 is still relevant to young scientists and PhD students who want to find the best synergy between detector, geometry and electronics, for the purpose of creating a cost-effective instrument with the highest efficiency of early cancer detection, while minimizing both the radiation dose to the patient and the examination cost.

Here is that sentence: “Design a cost-effective system (electronics + detector) with a long Field-Of-View that captures as many 511keV pairs of photons as possible from positron-electron annihilation and accurately measures each photon’s arrival time, energy, and  the x, y, z  coordinates of its impact point in the crystal. Moreover it must have the capability to efficiently exchange data with neighboring channels without boundaries, and to efficiently reject the noise by executing complex algorithms for a time longer than the time interval between two consecutive input data sets at the lowest cost per valid pair of 511 keV photons captured compared to current systems.”

The 3D-CBS technology with its innovations in electronics, detector assembly and coupling of the detector with the electronics will cause a paradigm shift in the Medical Imaging, enabling effective early cancer detection (CT, PET, SPECT), molecular physics, and true whole-body, 3D imaging.

The reason for this workshop is to understand why, after more than a decade, an invention like 3D-CBS technology, which could have already saved many lives and reduced health care costs through the early detection of cancer, has not been funded.   Information provided by 3D-CBS innovative technology can also be useful in investigating many other anomalies in a patient’s body (diabetes, Alzheimer’s, heart and vascular diseases, etc.), improve the treatment of patients, and open the door to the discovery of new biomarkers through its increased sensitivity. In fact Crosetto has been prevented from presenting his invention at several IEEE-NSS-MIC conferences. At the same time, some of the Chairmen and reviewers who rejected  3D-CBS and prevented its presentation received funding for less efficient projects, and are now building a similar device, although much more expensive.

 The need for this workshop is to develop a metric to establish a link between proposed research and the ultimate objective to reduce cancer deaths and cost, when compared with others projects, and to point out advantages and weaknesses. Participants are encouraged to estimate and propose a plan to measure the percentage of reduction in cancer deaths they expect to attain from their research stand-alone, or when combined with other existing components or with other research currently being developed. One example is testing on a sample population taken from a group aged 55-74 that has had a constant cancer death rate for the past 20 years. A difference or no difference in cancer death reduction will determine the success or failure of the proposed research.

The scope of this workshop is to summarize the state-of-the-art technological developments in the various fields of application for Medical Imaging and recognize those that have greater potential to reduce cancer deaths and cost. The limits of current systems should be analyzed. Crosetto will make a short presentation of his inventions that would have saved many lives and reduced health care cost. Leaders from leading universities and research centers in the field, including those who presented the Explorer at the 2013 IEEE-NSS-MIC-RTSD, will be invited to present their projects comparing them with others. Senior scientists, young scientists and PhD students will be invited to analyze the limits of current PET and to compare their approach for medical imaging systems in PET/CT, PET/MRI, PET/ultrasound, TOF-PET and any Imaging system (e.g. measuring fluorescence, tissue conductivity, etc.) that has potential to significantly reduce global cancer deaths and cost. This last phase will take place during the round table discussion.

 The benefits from this workshop will lead to the identification and funding of the best solutions with the highest potential to reduce cancer deaths and cost. This can be achieved through a public dialogue that is following scientific procedures where everyone is given the opportunity to present their contribution to the advancement of science in the field. In this way, reliable information can be placed on Wikipedia and no relevant contribution to the history of PET and Medical Imaging will be left out. Scientists have a great responsibility to provide ethical and professional information so that the possibility to solve the cancer problem increases.

It is foreseen to have introductory and overview talks during the first 90 minutes made by internationally recognized experts. The focus of the following 60 minutes will be short (5 minutes, including questions) oral presentations by young scientists and PhD students. The last 2 hours will be dedicated to a round table discussion extended to participants via web EVO system that is used by HEP teleconferencing and can be used by any individual. We encourage young researchers to present and discuss their work. The entire event will be broadcast worldwide by professionals in communication.

If you want to contribute to this workshop, please send your abstract through the conference website before June 15th. A preliminary program will be available in the conference booklet.

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