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Information, Awareness, Prevention / United to End Cancer

An invention constituting an important scientific advance for the detection and prevention of various cancers and other pathologies has been hampered if not compromised by the attitudes and obstructions of certain scientific, economic and political circlesSUMMARY 

1)      The author of this invention is Dario Crosetto, a 65-year-old research scientist who worked from 1975-88 on Gargamelle and Delphi experiments at CERN designing instrumentation and Level-2 Triggers from the University of Turin, Italy. He was employed by CERN as “Paid Scientific Associated” from 1988-89 where he was charged to design instrumentation for the Q-measurement project for the CERN SPS Accelerator and the FDPP Parallel-Processing project for the CERN Data Handling Division. In 1991 he joined the Superconducting Super Collider project in Texas, where he was charged to design the Level-1 Trigger for the GEM experiment. Since 1994 he has held the position of CEO of 3D-Computing, Inc. and since 2008 as President of Crosetto Foundation for the Reduction of Cancer Deaths.

 

2)      Crosetto’s research lead him to medical imaging where he focused on significantly reducing cancer deaths and costs and to develop a medical imaging device the 3D-CBS (3-D Complete Body Screening) with the following major features/characteristics (see details 2000, 2015):

  1. Increase in sensitivity by staggering amounts to detect minimum anomalies of biological processes with extreme precision providing essential information to patients and physicians that can help with the diagnosis, prognosis, and treatment of patients. These features make it particularly useful for diagnosing cancer and many other diseases at an early curable stage.
  2. Reduction in the radiation dose to one hundredth the current amount
  3. Reduction in the examination cost, making it accessible to a large population, thus having the potential to save many lives.

 

3)   Dario Crosetto worked on leading edge physics experiments at the world’s largest laboratories (CERN in Geneva, Superconducting Super Collider -SSC- Texas, FERMILAB and Brookhaven National Laboratory -BNL-). He won the Leonardo da Vinci Prize for his invention for early cancer detection, was awarded one million dollars in government grants (Department Of Energy and Department Of Defense), and received $10,000 for the best Business Plan reviewed by Venture Capitalists in a start-up competition.

 

4)   His inventions could create powerful, low-cost instruments for advancing science, discovering new subatomic particles and saving many lives with an effective early detection of cancer and many other diseases at a curable stage. They were recognized valuable since the mid-90’s in formal, public scientific reviews, presented at scientific conferences, published in peer-review scientific journals, and the concept of his basic invention was proven feasible and functional in hardware.

 

5)   The claim of saving many lives is proven from experimental data collected by several agencies in the world, including U.S. NIH Surveillance Epidemiology End Results (SEER), which shows that the survival rate of lung cancer when detected at an early stage is 49.5% compared to 2.8% when detected at a late stage and for prostate cancer, the survival rate when detected early is 100% compared to 31% when detected at a late stage. Crosetto’s inventions proven functional in Field Programmable Gate Array (FPGA) and feasible by the technology detailed in the 59 quotes from reputable industries, proves that items a), b) and c) of point 2 are achievable, which enable an effective early cancer detection, which saves lives.

 

6)   However, his inventions progressively encountered obstacles which have impeded for two decades the transfer of their benefits to the public health and the advancement of science.  Certain scientific, economic and political circles deny funding the implementation of Crosetto’s inventions by seeming to use non-scientific, untrue statements or by ignoring his proven inventions. At the same time, while Crosetto’s research is patented, some economic interests seem to take ownership of them, but at a pace and in procedures that suit them far better to maximize their profit.

 

7)   Dario Crosetto speaks today to various European and U.S. bodies, asking them for their support: his main objective is to obtain an in-depth, fair and unfettered public scientific debate and review with his peers. Because the key features of Crosetto’s inventions are related to the detection of particles that are common to the application of medical imaging in extracting all valuable information from the radiation from the tumor markers at the lowest cost per valid signal captured, it is essential to conduct this review at CERN in Geneva where there are the top world experts in particle detection. This will bring benefits not only to applications in physics and medical imaging but to many other fields which can benefit from Crosetto’s invention which breaks the speed barrier in real-time applications.

 

8)   All this deserves an in-depth journalistic investigation. Dario Crosetto is ready to meet any journalist who would like to explore this matter further. In the documentation below, he provides a great deal of detailed information with all the necessary links.

 

Contact Information for Dario Crosetto:

President of Crosetto Foundation for the Reduction of Cancer Deaths

900 Hideaway Pl.

DeSoto, TX 75115

Email: crosettodario@gmail.com

Phone: +1-972-223-2904


 

  1. DEVELOPMENTS

 

1)      In summary, Crosetto’s research led him to medical imaging where he focused on significantly reducing cancer deaths and costs and to develop a medical imaging device, the 3D-CBS (3-D Complete Body Screening) with the following major features/characteristics (see details 2000, 2015):

 

  1. Increase in sensitivity by staggering amounts to detect minimum anomalies of biological processes with extreme precision providing essential information to patients and physicians that can help with the diagnosis, prognosis, and treatment of patients. These features make it particularly useful for diagnosing cancer and many other diseases at an early curable stage.
  2. Reduction in the radiation dose to one hundredth the current amount
  3. Reduction the examination cost making it accessible to a large population, thus having the potential to save many lives.

 

Dario Crosetto  worked on leading edge physics experiments at the world’s largest laboratories (CERN in Geneva, Superconducting Super Collider -SSC- Texas, FERMILAB and Brookhaven National Laboratory -BNL-),won the Leonardo da Vinci Prize for his invention for early cancer detection, was awarded one million dollars in government grants (Department Of Energy and Department Of Defense), and received $10,000 for the best Business Plan reviewed by Venture Capitalists in a start-up competition.

 

His inventions could create powerful, low-cost instruments for advancing science, discovering new subatomic particles and saving many lives with an effective early detection of cancer and many other diseases at a curable stage. They were recognized valuable since the mid-90’s in formal, public scientific reviews, presented at scientific conferences, published in peer-review scientific journals, and the concept of his basic invention was proven feasible and functional in hardware.

 

Recently, Crosetto provided the blueprint of his basic 1993 and 2000 inventions augmented by additional inventions in 2015, that when applied to two specific fields: Physics with his 3D-Flow OPRA (Object Pattern Real-Time Recognition Algorithms) and early cancer detection with his 3D-CBS (3-D Complete Body Screening) have been proven feasible by 59 quotes from reputable industries to provide the following advantages/benefits.

 

–  In the field of Physics: In discovering new subatomic particles in High Energy Physics experiments, Crosetto’s new 3D-Flow OPRA (Object Pattern real-time Recognition Algorithms) can replace the Level-1 Trigger electronics at CERN’s Atlas and CMS experiments made of hundreds of crates housing 4,000 electronic data processing boards costing over $100 million (confined in a room 2,200 cm x 1,600 cm as reported in two slides and the first page of the paper) with one crate housing 9 data processing boards (described in 2 pages summary, detailed in 271 pages) having a staggering performance improvement costing only $100,000 for each duplicate system that can be used for Atlas, CMS and other experiments. Current Atlas and CMS Level-1 Triggers presented at the 2016 IEEE-NSS-MIC-RTSD conference are more expensive than Crosetto’s 3D-Flow system and do not have the capability to perform object pattern recognition on all data arriving at 0.65 TB/sec data rate and reduce the data rate based on their energy. An analogy, is throwing away the baby with the dirty water because the decision is based on the weight. Crosetto’s 3D-Flow system has instead the capability of analyzing objects at twice the rate of 1.3 TB/sec from all incoming data, and able to distinguish the shape of an object, like the baby analogy even if its weight matches the dirty water.

 

The proof that Atlas and CMS Level-1 Triggers do not work (See more details here):

  1. a) when the Higgs-like boson was announced on July 4, 2012, only 40 events were found out of 100,000 generated by the LHC machine,
  2. b) those 40 Higgs-like boson events were not found by the merit of the Level-1 Trigger but by analyzing trillions of events recorded casually,
  3. c) the scientists who built the 4,000 electronic data processing boards realized their electronics were not working and replaced them with another system having fewer numbers of data processing boards but still without the capability to perform object pattern recognition on all data, and therefore rejecting the majority of them based on their energy.

 

There is a scientific way to resolve disagreements

  1. a) to discuss analytically in a scientific forum at CERN the different systems based on calculations and
  2. b) to build a unit ER/DSU costing $50,000 that is recording data from the LHC apparatus and replay the data to the Level-1 Trigger built by Atlas, CMS and Crosetto’s 3D-Flow OPRA systems (See details of the ER/DSU unit from page 149 to 170 of the proposal). If this ER/DSU unit would have been built before 2012 it would have proven to the CMS and Atlas scientists that their Level-1 Trigger was not working and saved years of work and millions of dollars because theirs could not recognize even a fraction of the 100,000 Higgs-like boson events produced by the LHC.

Testing the new CMS and Atlas systems presented at the 2016 IEEE-NSS-MIC-RTSD conference rejecting most of the data based on a combination of thresholds on the energy will prove that it could not find even 50% of the Higgs-like boson events known and stored in the ER/DSU memory, while the 3D-Flow OPRA has the capability to recognize all (the majority) of Higgs-like boson because it performs an object pattern recognition on all of them.

 

–  In the field of cancer: Crosetto’s 3D-CBS (3-D Complete Body Screening) based on the 3D-Flow OPRA is making a paradigm change in molecular imaging providing the first tool for an effective early detection of cancer and other diseases at a curable stage to save lives. The 3D-CBS also provides a very powerful tool for research at a lower cost with respect to the Explorer project. The Explorer is limited in efficiency and performance because it does not have the capability to process 40,000 TB data per day at the front end and is instead performing the analysis of only 40 TB data per day at the back-end. The 3D-CBS has the capability to process over 40,000 TB data per day and is over ten times less expensive than the Explorer.

 

2) However, his inventions have progressively encountered obstacles which have impeded for two decades the transfer of their benefits to public health.

 

After the initial support of Crosetto’s inventions with DOE and DOD grants, his support faded, funding agencies and companies, instead of respecting the official recognitions of his inventions started copying them despite the fact they were protected by patents.

 

An analysis of facts and documents during the past two decades will reveal important reasons unfair to taxpayers and the public, that has stopped and is stopping the development of Crosetto’s inventions because of the economic and power interests of a few.

 

We assume that several obstacles could explain the suppression, boycotting and lack of funding for Crosetto’s medical imaging inventions which increase the efficiency, reduce the radiation and reduce the examination cost.

 

Just to list a few:

 

  1. a) the amortization of the investment companies manufacturing PET (PET/CT, PET/MRI, etc.) have made on their devices before making a big change from 16 cm detector length (FOV) to 150 cm,

 

  1. b) it is more profitable for manufacturing companies to increase the efficiency of the device gradually by increasing the FOV from 16 cm to 25 cm to 40 cm…, and asking the hospitals to update their device every 2 years with $2 million revenue for many years, than increase the FOV to 150 cm without small increments,

 

  1. c) the monopoly of a few companies (three) sharing the PET (PET/CT) over $1 billion market per year, and

 

  1. d) many other reasons that will emerge from the investigation for example that it is more profitable for pharmaceutical companies to sell chemotherapy drugs for cancer detected at a late stage when the patient is less likely to survive than selling the drugs when cancer is detected at an early curable stage, eliminating the need to continue the drugs for the rest of their lives as patients with heart disease must.

 

In the field of research to advance science, e.g. to discover new subatomic particles, we assume that several obstacles could explain the suppression, boycotting and lack of funding for Crosetto’s inventions because of the power of colleagues who allocate billions of dollars assigned from public funding agencies such as the European Commission, U.S. Department of Energy, U.S. National Institutes of Health, governments of different countries, private cancer organizations or other organizations using donation money to fund research and humanitarian causes. All these organizations and philanthropists refer and trust the evaluation of scientists expert in the field who are supposed to give them the best advice to achieve their scientific results and/or humanitarian goals.

 

Influential scientists want to control the billions of dollars of taxpayer money by distributing the money among their circle of friends with no accountability in complying with the ethics of a scientist, without following scientific public procedures based on analytical discussions supported by calculations and scientific evidence to make the scientific truth for the benefit of humanity emerge.

 

They avoid accountability, and approve their articles and fund their projects using anonymous reviewers who make non-scientific and/or untrue statements.

 

However, because they are anonymous their scientific integrity and credibility is not at risk and does not suffer. Furthermore, no one at a higher lever who appointed the anonymous reviewers or who should guarantee a scientific procedure claim to be responsible to overturn a rejection of an article or fund a project even if the anonymous reviewer makes a non-scientific statement such as the earth is at the center of the universe, or makes an untrue statement that can be proven wrong.

 

The claim of saving many lives is proven from experimental data collected by several agencies in the world, including U.S. NIH Surveillance Epidemiology End Results (SEER), which shows that the survival rate of lung cancer when detected at an early stage is 49.5% compared to 2.8% when detected at a late stage and for prostate cancer, the survival rate when detected early is 100% compared to 31% when detected at a late stage. Crosetto’s inventions proven functional in Field Programmable Gate Array (FPGA) and feasible by the technology in the 59 quotes from reputable industries, proves that items a), b) and c) of point 2, are achievable, which enable an effective early cancer detection, which saves lives. Proof that the 3D-CBS invention capable of delivering at once the three features a) a staggering increase in sensitivity, b) a 100 times reduction in the radiation, c) a reduction in the examination cost, can save many lives is much stronger than the opinions of any prominent scientists because it relies on experimental data collected by SEER and several agencies in the world proving that early detection save lives, and it relies on calculations, data sheets, technologies, that exist and are verifiable. The benefits of increasing sensitivity, focusing on the improvement of the electronics, etc. are now accepted by several people who before were focused on improving crystals, spatial resolution, etc., including the authors of the Explorer project; however, because technology, data sheets and calculations are verifiable it can also strongly refute anyone who would claim the contrary that the 3D-CBS which maximizes these three features cannot provide a staggering increase in saving lives and reducing healthcare costs. The most skeptical people can be convinced by a test on a sample population; however, funding is urgently needed to build the 3D-CBS before additional lives are lost needlessly.

 

When Crosetto invented the 3D-CBS in the year 2000 he believed he would be failing in his duty as a scientist if he did not inform the scientific community and those in power in the field about his invention that would benefit humanity. Therefore, he presented two articles and a technical-scientific book entitled:”400+ times improved PET efficiency for lower-dose radiation, lower-cost cancer screening” 200 copies of which he distributed free of charge to the leaders in the field at the 2000 IEEE-NSS-MIC Conference.

 

In an ideal, civilized world governed by the “rule of law” and where scientists with ethics and professional integrity state what they understand to be the “laws of nature” and support ideas/projects/inventions with “highest scientific merits” the following logical steps should bring benefits to humanity: This ideal, civilized world existed to some extend in 1993 when Crosetto’s basic 3D-Flow invention was formally, publicly, officially recognized by academia, industries and research centers in a major public scientific review at FERMILAB and was funded immediately with $150,000 to save his idea in documents and in 1995 with $1 million in grants to prove it feasible. However, the scientific world changed after 1995 when billions of dollars of taxpayer money went into large physics experiments such as LHC and scientific merits faced the power of money, like in the billion dollars healthcare business, rather than a rigorous analytical public scientific review based on calculation, data sheets of different technologies and scientific evidence.

 

To bring the benefits to humanity from inventions, Crosetto or any inventor need first the approval of the influential players in the field who should recommend government funding agencies to fund prototypes of projects with higher scientific merits and higher potential to reduce cancer deaths and costs. Before disclosing an invention to anyone, Crosetto or any inventor should have protected his invention with patents. The logical path of Crosetto’s invention after protecting his idea with patents as he did and submitting it to influential players in the field who should provide government funding to build the prototype, would be to attract industries to mass produce a device that would benefit a large number of the population. Therefore, Crosetto started with the step of asking Terry Jones (who is now one of the authors of the Explorer project), a prominent leader in the field if he could review his technical-scientific book.

 

Jones appointed Steve DeRenzo as the technical expert in the field to review Crosetto’s book. Crosetto has known DeRenzo since 1992 when he was working at the Superconducting Super Collider and realized he had difficulties addressing scientific arguments about one of his articles with him and his colleague, Bill Moses (who is now one of the authors of the Explorer project) who were both working at Lawrence Berkley Laboratory and were both influential in the field.

 

Despite the very favorable reviews of Crosetto’s book on Amazon.com, the reviews by influential scientists were negative. DeRenzo stated in his review of Crosetto’s book: We do not view the electronics as a problem, either in terms of performance or cost”.

In fact, because Crosetto’s invention did not follow the main stream direction in research of improving crystals, PET spatial resolution, to the detriment of sensitivity, his more than a dozen proposals, over a period of ten years to the National Institutes of Health, Department of Energy, National Science Foundation were all rejected,  and Crosetto had to use his own money to build two modular electronic boards to prove the feasibility and functionality of his invention.

 

It took 15 years from when Crosetto wrote his book and 19 years from his first rejection for funding by NIH, for those in power in the field such as Bill Moses to reverse their position on Crosetto’s direction of research that they have obstructed for years.  Read Moses’ 2015 press release: «We’re developing the electronic interface between the detectors and the computer algorithm—and the electronics for this scanner is an order of magnitude more complicated than what’s been done before,” says Moses».

 

However, 160 million people have died from cancer since Crosetto first claimed that to improve PET medical imaging efficiency it is necessary to improve the electronics and not the crystals. Many of these people could have been saved if funding agencies had requested a public review of Crosetto’s invention similar to the major scientific review of his basic 3D-Flow invention held at FERMILAB in 1993.

 

If the peer review system of articles, NIH and other funding agencies continues to assign taxpayer money in closed door meetings among a circle of friends, how many more deaths and years will it take before an analytical and scientific discussion of Crosetto’s invention is accepted instead of funding the Explorer which is less efficient and over ten times as expensive as the 3D-CBS? Instead, in 2016 NIH continues to refuse to set a meeting with Crosetto that has been promised for two years to discuss scientific issues analytically, based on calculations, data sheets of technologies, quotes from industries, scientific evidence of advantages in saving lives and reducing healthcare costs and his papers continue to be rejected with non-scientific, untrue statements.

 

Facts will prove that government agencies do not ask questions over what they do not understand in a proposal or a quote from an industry in a formal request for funding; they deny the dialogue from the PI who could explain to reviewers the existence of technology that they might be unaware of; and at least one has deleted official records of submissions for a request for funding and all emails exchanged in this matter including a self-incriminating email.

 

This is what happened recently with Glen Crawford, Director of Research and Technology at the U.S. Department of Energy, who never responded for two years to emails related to his job description, even when his supervisor told him to communicate with Crosetto. Crawford then wrote a self-incriminating email to Crosetto, but all official records of Crosetto’s proposal, including Crawford’s self-incriminating email and other emails between Crosetto and Crawford’s supervisor, Jim Siegrist, were wiped clean from the DOE record as reported by FOIA (Freedom of Information Act) after Crosetto requested a copy of all records related to his case to DOE.

 

Crosetto is doing all he can to reduce the waste of taxpayer and donation money on less efficient, more expensive technology knowing of the existence for two decades of more efficient and less expensive technology; however, he cannot do it alone.

 

On November 3 and 4, 2016, he distributed 650 copies of his papers/inventions to the participants of the IEEE-NSS-MIC conference in Strasbourg, France. He attended the presentations of the CMS and Atlas competing projects and asked the presenters questions which confirmed that their systems do not perform object pattern recognition on all data but reject most of them based on a threshold of the weight. At the same conference, he explained his system to several leaders in the field, including two General Chairmen of previous IEEE-NSS-MIC conferences. He explained his 3D-Flow OPRA for 20 minutes in a meeting with the former CERN Director of research who did not refute any part of his presentation, but stated that this project should be presented at CMS, Atlas, etc. The former CERN Director of Research was surprised that the project was rejected at the conference. Crosetto spent 100 minutes with the current President of IEEE, John Verboncoeur, and the newly elected President, Stefan Ritt, who will take charge next year. Neither refuted any part of Crosetto’s project. They presented a deal to Crosetto for him to postpone the review of his papers content with a special attention from the President for one more year. Crosetto already explained in a previous message that this deal was not acceptable because the President could not guarantee a fair review, and so it would continue to be subjected to the power of anonymous reviewers, and would delay for one more year the benefits of his inventions to humanity.  Meanwhile 7.5 million people will die from cancer while many could be saved (statistics form SEER prove over 50%) with an effective early detection.

 

Crosetto also informed the European Commission, Members of the European Parliament, etc. on several occasions about inconsistencies in science that need to be addressed, in particular about the rigged peer-review system.

 

On June 4, 2015, a member of the European Parliament, Hon. Alessia Mosca, submitted an interrogation to the European Commission with a request for a written answer. The response did not address the specific question of the interrogation.

 

On June 23, 2016, Crosetto, together with Judge Antonino Abrami and inventor, Fabrizio Tamburini met Hon. Giovanni La Via, President of the Commission for Environment, Health and Food Safety requesting an audition for their inventions at the European Parliament, which is now being evaluated.

 

On November 8, 2016, Crosetto was received by the President of the Socialists & Democrats, Hon. Gianni Pittella in his office at the European Parliament in Brussels for 25 minutes.  He listened with interest to his story, took Crosetto’s handout that was distributed in 650 copies the prior week to the scientists at the conference, and asked what he could do to help. Crosetto explained that the first important issue is to discuss publicly in a scientific review at CERN his invention in a review similar to the one held at FERMILAB on December 14, 1993. Hon. Pittella mentioned that he had planned a visit to the Director of CERN, Fabiola Gianotti, in the near future, then called his assistant, wrote a note and promised that he would ask her to conduct this scientific review.

 

During the same visit at the European Parliament, Crosetto visited the office of Hon. Alessia Mosca and Hon. Giovanni La Via informing their assistants about the conference the week before and leaving a copy of the six-page handout. Dr. La Via’s assistant, Dr. Dario Siggia invited Crosetto to submit preliminary documentation for the request of an audition within a week, which was provided on November 14, 2016, and asked for guidance to fulfill all requirements.

 

Because the key features of Crosetto’s inventions are related to detection of particles that are common to the application in medical imaging in extracting all valuable information from the radiation from the tumor markers at the lowest cost per valid signal captured, it is essential to conduct this review at CERN in Geneva where there are the top world experts in particle detection. This will bring benefits not only to applications in physics and medical imaging, but to many other fields which can benefit from Crosetto’s invention which breaks the speed barrier in real-time application.

 

It is extremely important and urgent that investigative journalists and agencies collect all material Crosetto has accumulated during these two decades and inform the public so that they can strongly support the request for transparency in science that will swiftly bring to humanity the benefits of Crosetto’s innovations.

 

All this material is available upon request to reveal the truth to create a better world:

Dario Crosetto, 900 Hideaway Pl.  DeSoto, TX 75115. crosettodario@gmail.com Tel. 1-972-223-2904

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